Valeria Grazú Lab
Laboratory led by Valeria Grazú within the Bionanosurf research group.
Lab summary
Valeria Grazú’s research combines the selectivity of enzymatic catalysis with nanoactuated materials that can be remotely activated to generate localized heat, enabling remote control of catalytic activity. The lab designs enzyme–nanomaterial hybrids in which external stimuli, such as alternating magnetic fields or light, induce localized temperature increases in responsive nanomaterials (including magnetic nanoparticles, photothermal gold nanostructures, and thermoresponsive materials).
This approach enables enzymes to operate at different optimal temperatures within the same environment without changing the global temperature. The work draws on long-standing expertise in the oriented immobilization of complex biomolecules across multiple material platforms, supporting applications in industrial bioprocessing and therapeutic strategies such as spatiotemporally controlled activation of prodrugs in cancer therapy.
Lab quick facts
- ORCID: 0000-0001-6170-4237
Team
- Liliane Beola
- Nicolás Casinelli
- Francesca Busolari
- Marcos Orduña
- Valeria Grazú Bonavía
- Cristina Flavian
- Lucía Pérez Jiménez
Latest publications
-
Heat up, silence on: IDO1 gene silencing in THP-1-derived dendritic cells triggered by magnetic hyperthermiaCancer Immunology, Immunotherapy · August 23, 2025
-
Opportunities for nanomaterials in enzyme therapyJournal of Controlled Release · June 29, 2024
-
Biophysical evaluation of antiparallel triplexes for biosensing and biomedical applicationsInternational Journal of Biological Macromolecules · February 29, 2024
-
Spatio-temporal selectivity in chemotherapy: remote activation of enzymatic nanohybrids for prodrug therapyJanuary 1, 2024
-
MONITORING THE ACTIVATION OF MAGNETIC NANOPARTICLES BY ELECTRON PARAMAGNETIC RESONANCEJanuary 1, 2024