About Bionanosurf

Institutional origin and mission

Bionanosurf is a consolidated research group recognised by the Regional Government of Aragón (DGA) and based at the Aragon Nanoscience and Materials Institute (INMA), the joint centre operated by CSIC and the University of Zaragoza. Over more than a decade, the group has advanced nanomedicine, surface chemistry, magnetic systems, biosensing, and translational technologies to address diagnostic and therapeutic challenges.

Our laboratories combine chemists, physicists, biologists, and engineers who work side-by-side on the design of functional nanoparticles, their interaction with biological environments, and collaborations with clinical and industrial partners.

Scientific focus

A unified pipeline from molecular design to transfer

Our four axes—therapeutic nanoconjugates, magnetic nanoactuators, nanobiosensors, and quality & transfer—form a continuous pathway. We study how nanoparticles behave in complex environments, engineer their physical properties for function, and measure how nanoscale processes drive biological responses. This integrated approach lets us tackle infectious diseases, oncology, rare conditions, and advanced diagnostics while partnering with clinicians and industry to move promising ideas toward real-world applications.

People

A multidisciplinary team

The group brings together permanent researchers, postdoctoral scientists, doctoral students, technicians, project managers, and undergraduate trainees. Expertise spans nanomaterials synthesis, supramolecular chemistry, molecular biology, biophysics, magnetic characterisation, microscopy, microfabrication, and data analysis. Bionanosurf also collaborates with national and international partners in academia, hospitals, and industry through European projects, technology transfer initiatives, and clinical-oriented programmes.

How we work

Iterative experimentation anchored in quality

We combine experimental design, advanced characterisation, and biological assessment to iteratively refine materials and devices. Complementary techniques—from surface chemistry and spectroscopy to magnetic and optical measurements, cell models, and preclinical assays—help us understand how nanoscale properties influence therapeutic and diagnostic performance.

Reproducibility and quality are central to our work. The group develops shared protocols aligned with GLP/GMP principles and leverages INMA’s integrated infrastructure for materials processing, biological testing, and data workflows.

Impact

Why this research matters

Nanotechnology enables earlier disease detection, precise therapies, and deeper insight into biological mechanisms. By integrating materials science, physics, chemistry, and biomedicine, Bionanosurf aims to deliver technologies that improve diagnosis, contribute to personalised interventions, and support safer, more effective medical solutions.

Leadership

The group is led by Jesús Martínez de la Fuente, whose work focuses on functional nanoparticles, magnetic systems, and plasmonic biosensing for biomedical applications.

Research Highlights

Translating nanotechnology from concept to clinic

The group’s activity is organised into four axes that reflect a complete research pathway—from synthesis and biofunctionalisation to validation and transfer.

Axis A

Nanoconjugates & therapeutic delivery

Multifunctional nanoconjugates based on natural and synthetic polymers engineered to transport antibiotics, siRNA, antimicrobial peptides or inorganic nanoparticles. These systems target infections such as tuberculosis, as well as pancreatic and colon cancer and specific rare diseases.

Learn about controlled delivery

Axis B

Magnetic nanoactuators

Magnetic nanoparticles capable of generating heat under external fields to modulate enzymes, receptors and cellular pathways. These systems support controlled release, mechanobiological studies and remote actuation strategies relevant to oncology and biosensing.

View magnetic actuator studies

Axis C

Nanobiosensors

Lateral-flow and calorimetric biosensing platforms that use plasmonic nanoparticles to achieve femtomolar sensitivity. Applications include liquid biopsy approaches for early pancreatic cancer detection and point-of-care diagnostics for respiratory viruses such as SARS-CoV-2, influenza and RSV.

Dive into biosensing

Axis D

Quality & technology transfer

Protocols aligned with GLP/GMP principles and shared processes that connect INMA infrastructures, materials characterisation, biological testing and regulatory knowledge. These frameworks support the safe, efficient and reproducible transfer of nanoformulations and medical nanodevices.

See translational standards