Raluca Fratila Lab
Laboratory led by Raluca Fratila within the Bionanosurf research group.
Lab summary
Raluca Fratila’s research focuses on developing bioorthogonal click chemistry reactions for nanotechnology applications. She pioneered the use of bioorthogonal chemistry to covalently immobilize magnetic nanoparticles on the surface of living cells to investigate sub-lethal magnetic hyperthermia in cellular systems and understand how membrane-localized heating affects subcellular signalling pathways and the biophysics of cell membranes.
In parallel, the lab applies bioorthogonal strategies to immobilize magnetic nanoparticles on cell membranes for magneto-mechanical actuation, including the activation of mechanosensitive ion channels.
Lab quick facts
- ORCID: 0000-0001-5559-8757
Team
- Mariarosaria de Simone
- Christian Castro Hinojosa
- Raluca M. Fratila
- Sara Huerta Cebollada
Latest publications
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Precise-engineering of monodisperse magnetite nanoparticles with low-level of cobalt doping for enhanced MRI contrast performanceMaterials & Design · February 1, 2026
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MagPiezo: A Magnetogenetic Platform for Remote Activation of Endogenous Piezo1 Channels in Endothelial CellsAdvanced Functional Materials · January 1, 2026
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Heat up, silence on: IDO1 gene silencing in THP-1-derived dendritic cells triggered by magnetic hyperthermiaCancer Immunology, Immunotherapy · August 23, 2025
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Nanoparticle-assisted targeting of heart lesions with cardiac myofibroblasts: Combined gene and cell therapyTheranostics · March 18, 2025
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Nanomaterials in biotechnology – Current topicsJanuary 1, 2025